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Comparison between the Hypolipidemic Activity of Parsley and Carob in Hypercholesterolemic Male Rats
Hypercholesterolemia is commonly associated with obesity that leads to heart diseases and diabetes. The hepatocardioprotective activity of parsley and caro
Haddad A. El Rabey, Madeha N. Al‐Seeni, Habibah B. Al-Ghamdi
BioMed Research International · 2017 · https://doi.org/10.1155/2017/3098745
Abstract
Hypercholesterolemia is commonly associated with obesity that leads to heart diseases and diabetes. The hepatocardioprotective activity of parsley and carob methanol extract was tested in hypercholesterolemic male rats. Twenty-four male albino rats were divided into four groups (<mml:math xmlns:mml=”http://www.w3.org/1998/Math/MathML” id=”M1″><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn fontstyle=”italic”>6</mml:mn></mml:math>). Group 1 was the negative control group fed with fat rich diet, group 2 (G2) was hypercholesterolemic rats fed with fat rich diet with 2% cholesterol, and group 3 and group 4 (G3 and G4) were hypercholesterolemic rats supplemented with 2% cholesterol and cotreated with 20% w/w parsley seed methanol extract and 20% w/w carob legume methanol extract, respectively. The experiment was conducted for eight weeks. The positive hypercholesterolemic rats showed significant increase in serum levels of total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), lactate dehydrogenase (LDH), creatine kinase-mb, liver function enzymes, and decrease in the high density lipoproteins (HDL). Moreover, heart and liver tissues were ameliorated and nearly restored their normal appearance. It could be concluded that both parsley and carob extracts supplementations have a protective effect against hyperlipidemia and improved the histological alteration in heart and liver tissues. The methanol extract of parsley appeared to be more efficient than that of carob in lowering hypercholesterolemia.
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How to credit this work
Haddad A. El Rabey; Madeha N. Al‐Seeni; Habibah B. Al-Ghamdi (2017). Comparison between the Hypolipidemic Activity of Parsley and Carob in Hypercholesterolemic Male Rats. BioMed Research International. https://doi.org/10.1155/2017/3098745 Licensed under Creative Commons Attribution 4.0 (https://creativecommons.org/licenses/by/4.0/). Hosted by EVEC Athens (microgreens.org.gr). No changes were made to this article. Provided as-is, without warranties. EVEC Athens is not affiliated with, and this copy is not endorsed by, the authors or the publisher.
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